Lowered Female Fertility Associated with Human Papilloma Virus Vaccines


  • Gayle DeLong




The falling birth rate in the United States may be owed to multiple factors, the human papilloma virus (HPV) vaccines being among them. Here I examine again the hypothesis that the likelihood of having been pregnant at least once was reduced for women aged 25 to 29 between 2007 and 2018 who received one of the HPV vaccines compared with peers who did not. Data from the National Health and Nutrition Examination Survey (NHANES) representing 7.5 million women in the United States were used. The age-range was limited in order to compare women in the optimal age-range for child-bearing who received at least one HPV shot during the study period against peers who did not. Given that the HPV vaccines are aimed at preventing cervical cancer, but not at reducing or enhancing fertility, the opportunity and choice to receive such a vaccine should be about equal across all the women in the sampled age-range and time frame. Analysis revealed that only 47% of HPV vaccine recipients had ever conceived as contrasted with 69% of comparable peers who did not receive any HPV shot. If pregnancies after receiving such a shot were unaffected by it, the women in both groups should be equally likely or unlikely to get pregnant. Nevertheless, even when covariate controls for marital status, age, education, income, race/ethnicity, obesity and smoking were used, a multivariate logistic regression showed a reduced likelihood of pregnancy in the HPV vaccinated women (OR 0.66; 95% CI 0.438, 0.998): women who received the HPV vaccine were less likely to have been or to become pregnant during the time frame examined. The reasonable conclusion is that receiving an HPV vaccination reduces female fertility. If the shot were aiming to be a birth-control vaccine the observed result would not be anomalous. But it is, and there is other research showing that at least two of the viruses targeted by all the HPV vaccines on the market, 16 and 18, can cause sterility in both females and males and are also associated with so-called “spontaneous” abortions and premature ovarian failure in pregnant female carriers of those pathogens.


Adamy, J. (2020, May 20). U.S. Birth rates Fall to Record Low. Wall Street Journal. https://www.wsj.com/articles/u-s-birth rates-fall-to-record-low-11589947260

Alves, C., & Rapp, A. (2021). Spontaneous Abortion. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK560521/

Broudy, D. (2021). Vaccine Development and Social Control:A Psychopathology of Impaired Reasoning in the Global Push for Mass Compliance. International Journals of Vaccine Theory, Practice, and Research, 2(1), 93–124. https://www.ijvtpr.com/index.php/IJVTPR/article/view/29/55

Centers for Disease Control and Prevention. (2020, September 16). HPV-Associated Cancer Statistics | CDC. https://www.cdc.gov/cancer/hpv/statistics/index.htm

Chen, Q., Di, Z., García Roger, E. M., Li, H., Richmond, P., & Roehner, B. M. (2020). Magnitude and significance of the peak of early embryonic mortality. Journal of Biological Physics, 46(3), 233–251. https://doi.org/10.1007/s10867-020-09555-4

Children’s Health Defense Team. (2021). Planned Surveillance and Control by Global Technocrats: A Big-Picture Look at the Current Pandemic Beneficiaries. International Journal of Vaccine Theory, Practice, and Research, 1(2), 143–171. https://ijvtpr.com/index.php/IJVTPR/article/view/7

Colafrancesco, S., Perricone, C., Tomljenovic, L., & Shoenfeld, Y. (2013). Human papilloma virus vaccine and primary ovarian failure: Another facet of the autoimmune/inflammatory syndrome induced by adjuvants. American Journal of Reproductive Immunology, 70(4), 309–316. https://doi.org/10.1111/aji.12151

Davidson, R. M., Lauritzen, A., & Seneff, S. (2013). Biological water dynamics and entropy: A biophysical origin of cancer and other diseases. Entropy, 15(9), 3822–3876. https://doi.org/10.3390/e15093822

Davidson, R. M., & Seneff, S. (2012). The initial common pathway of inflammation, disease, and sudden death. Entropy, 14(12), 1399–1442. https://doi.org/10.3390/e14081399

DeLong, G. (2018). A lowered probability of pregnancy in females in the USA aged 25-29 who received a human papillomavirus vaccine injection. Journal of Toxicology and Environmental Health. Part A, 81(14), 661–674. https://doi.org/10.1080/15287394.2018.1477640

DeLong, G. (2019). Letters to the editor; Response to: A possible spurious correlation between human papillomavirus vaccination introduction and birth rate change in the United States. Hum Vaccin Immunother, 15(10), 2503–2504. https://doi.org/open-access article available at https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1622977

Depuydt, C. E., Beert, J., Bosmans, E., & Salembier, G. (2016). Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin. Facts Views and Vision in Obgyn, 8(4), 211–222. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5303699/

Depuydt, C. E., Verstraete, L., Berth, M., Beert, J., Bogers, J.-P., Salembier, G., Vereecken, A. J., & Bosmans, E. (2016). Human Papillomavirus Positivity in Women Undergoing Intrauterine Insemination Has a Negative Effect on Pregnancy Rates. Gynecologic and Obstetric Investigation, 81(1), 41–46. https://doi.org/10.1159/000434749

Dotan, A., Kanduc, D., Makatsariya, A., & Shoenfeld, Y. (2021). Molecular mimicry between SARS-CoV-2 and the female reproductive system. Am J Reprod Immunol., Epub ahead of print. https://doi.org/10.1111/aji.13494.

Esposito, S., Prada, E., Mastrolia, M. V., Tarantino, G., Codecà, C., & Rigante, D. (2014). Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): Clues and pitfalls in the pediatric background. Immunologic Research, 60(2), 366–375. https://doi.org/10.1007/s12026-014-8586-0

Eurostat. (2020). Statistics | Eurostat. https://ec.europa.eu/eurostat/databrowser/view/DEMO_FRATE__custom_50940/default/table?lang=en

Fleming, R. (2021). Is COVID-19 a Bioweapon? Skyhorse Publishing.

French, F. E., & Bierman, J. M. (1962). Probabilities of Fetal Mortality. Public Health Reports (1896-1970), 77(10), 835–847. https://doi.org/10.2307/4591645

Garolla, A., Engl, B., Pizzol, D., Ghezzi, M., Bertoldo, A., Bottacin, A., Noventa, M., & Foresta, C. (2016). Spontaneous fertility and in vitro fertilization outcome: New evidence of human papillomavirus sperm infection. Fertility and Sterility, 105(1), 65-+. https://doi.org/10.1016/j.fertnstert.2015.09.018

Geier, D. A., & Geier, M. R. (2017). Quadrivalent human papillomavirus vaccine and autoimmune adverse events: A case-control assessment of the vaccine adverse event reporting system (VAERS) database. Immunol Res, 65(1), 46–54. https://doi.org/10.1007/s12026-016-8815-9 10.1007/s12026-016-8815-9 [pii]

Government of Canada, S. C. (2008, December 23). Primary sampling unit (PSU) masking and variance estimation in complex surveys—ARCHIVED. https://www150.statcan.gc.ca/n1/en/catalogue/12-001-X200800210759

Gruber, N., & Shoenfeld, Y. (2015). A link between human papilloma virus vaccination and primary ovarian insufficiency: Current analysis. Current Opinion in Obstetrics and Gynecology, 27(4), 265–270. https://doi.org/10.1097/GCO.0000000000000183

Gryder, B., Nelson, C., & Shepard, S. (2013). Biosemiotic entropy of the genome: Mutations and epigenetic imbalances resulting in cancer. Entropy, 15(1), 234–261. https://doi.org/10.3390/e15010234

Hamilton, B., Lu, L., Chong, Y., & et al. (2020). Natality trends in the United States. https://data.cdc.gov/NCHS/NCHS-Birth-Rates-for-Females-by-Age-Group-United-S/yt7u-eiyg/data

Hassold, T., & Hunt, P. (2001). To err (meiotically) is human: The genesis of human aneuploidy. Nature Reviews. Genetics, 2(4), 280–291. https://doi.org/10.1038/35066065

Hertzpicciotto, I., & Samuels, S. J. (1988). Incidence of Early Loss of Pregnancy. New England Journal of Medicine, 319(22), 1483–1484. https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.1056%2FNEJM198812013192214&DestApp=DOI&SrcAppSID=7BsUEfei6wy4FkKUFlC&SrcJTitle=NEW+ENGLAND+JOURNAL+OF+MEDICINE&DestDOIRegistrantName=New+England+Journal+of+Medicine

Huber, S., Bookstein, F. L., & Fieder, M. (2010). Socioeconomic status, education, and reproduction in modern women: An evolutionary perspective. Am J Human Biol, 22(5), 578–587. https://doi.org/10.1002/ajhb.21048

Informa, Chairman Derek Mapp. (2021). Combination and Creation: Annual Report and Financial Statements 2018. Informa. https://www.informa.com/investors/annual-report/

Informa Group. (2021). Taylor & Francis Journals. Taylor & Francis Group. http://taylorandfrancis.com/journals/

Jarvis, G. E. (2016). Early embryo mortality in natural human reproduction: What the data say. F1000Research, 5, 2765. https://doi.org/10.12688/f1000research.8937.2

Jaynes, E. T. (1957a). Information theory and statistical mechanics. I. Physical Review, 106(4), 620–630. https://doi.org/10.1103/PhysRev.106.620

Jaynes, E. T. (1957b). Information theory and statistical mechanics. Ii. Physical Review, 108(2), 171–190. https://doi.org/10.1103/PhysRev.106.620

Jaynes, E. T. (1965). Gibbs vs Boltzmann Entropies. American Journal of Physics, 33(5), 391. https://doi.org/10.1119/1.1971557

Kavanaugh, M. L., Jerman, J., & Finer, L. B. (2015). Changes in Use of Long-Acting Reversible Contraceptive Methods Among U.S. Women, 2009-2012. Obstet Gynecol, 126(5), 917–927. https://doi.org/10.1097/AOG.0000000000001094

Kennedy, D., Seneff, S., Davidson, R. M., Oller, J. W., Haley, B. E., & Masters, R. D. (2016). Environmental toxicants and infant mortality in America. Peertechz Journal of Biological Research and Development, 1(1), 36–61. https://www.peertechzpublications.com/articles/OJBS-1-105.php

Kennedy, R. F., Jr. (2021). The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health. Skyhorse Publishing. https://www.simonandschuster.com/books/Thimerosal-Let-the-Science-Speak/Robert-F-Kennedy/9781632206015

Lazarus, R., Klompas, M., Bernstein, S., & Harvard Pilgrim Health Care, Inc. (2010). Electronic Support for Public Health–Vaccine Adverse Event Reporting System (ESP-VAERS) (p. 7). Harvard Pilgrim Health Care, Inc. https://healthit.ahrq.gov/sites/default/files/docs/publication/r18hs017045-lazarus-final-report-2011.pdf

Lee, S. H. (2020). Toll-like Receptor 9 Agonists in HPV Vaccine Gardasil9. International Journal of Vaccine Theory, Practice, and Research, 1(1), 75–97. https://ijvtpr.com/index.php/IJVTPR/article/view/5

Little, D. T., & Ward, H. R. (2012). Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination. BMJ Case Rep, 2012. https://doi.org/bcr-2012-006879 [pii] 10.1136/bcr-2012-006879

Little, D. T., & Ward, H. R. (2014). Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination: A Case Series Seen in General Practice. Journal of Investigative Medicine High Impact Case Reports, 2(4), DOI 10.1177/2324709614556129. https://doi.org/10.1177/2324709614556129

Markowitz, L. E., Dunne, E. F., Saraiya, M., Chesson, H. W., Curtis, C. R., Gee, J., Bocchini, J. A., & Unger, E. R. (2014). Human papillomavirus vaccination: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep, 63(RR-05), 1–30. https://doi.org/rr6305a1 [pii]

Medicalbiostatistics. com. (2018, May 11). Relative risk, odds ratio, attributable risk and number needed to treat. http://www.medicalbiostatistics.com/rr-or-etc.pdf

Meites, E., Gee, J., Unger, E., & Markowitz, L. (2020). Human Papillomavirus. In Centers for Disease Control (Ed.), Pinkbook: Epidemiology of Vaccine Preventable Diseases. https://www.cdc.gov/vaccines/pubs/pinkbook/hpv.html

Naim, N., Amrit, F. R. G., McClendon, T. B., Yanowitz, J. L., & Ghazi, A. (2020). The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology, 42(12), e2000103. https://doi.org/10.1002/bies.202000103

Nayak, P. (2002). Aluminum: Impacts and Disease. Environmental Research, 89(2), 101–115. https://doi.org/10.1006/enrs.2002.4352

NCHS - Birth Rates for Females by Age Group: United States. (2020). Centers for Disease Control and Prevention. https://data.cdc.gov/NCHS/NCHS-Birth-Rates-for-Females-by-Age-Group-United-S/yt7u-eiyg

Oller, J. W. (2010). The antithesis of entropy: Biosemiotic communication from genetics to human language with special emphasis on the immune systems. Entropy, 12(4), 631–705. https://doi.org/10.3390/e12040631

Oller, J. W. (2014). Biosemiotic entropy: Concluding the series. Entropy, 16(7), 4060–4087. https://doi.org/10.3390/e16074060

Oller, J. W. (2020). Introducing Child Language Development: For Teachers, Parents, Researchers, and Theoreticians about the Five Ells—Love, Life, Learning, Language, and Literacy in that Order (1st ed.). Sentia. https://www.sentiapublishing.com/education/introducing-child-language-development-for-teachers-parents-researchers-and-theoreticians-about-the-five-ells-love-life-learning-language-and-literacy-in-that-order-oller-online-textbook/

Oller, J. W., & Shaw, C. A. (2019). From superficial damage to invasion of the nucleosome: Ranking of morbidities by the biosemiotic depth hypothesis. International Journal of Sciences, 8(06), 51–73. https://doi.org/10.18483/ijSci.2069

Oller, J. W., Shaw, C. A., Tomljenovic, L., Karanja, S. K., Ngare, W., Clement, F. M., & Pillette, J. R. (2017). HCG found in WHO tetanus vaccine in Kenya raises concern in the developing world. OALibJ, 04(10), 1–30. https://doi.org/10.4236/oalib.1103937

Oller, J. W., Shaw, C. A., Tomljenovic, L., Ngare, W., Karanja, S., Pillette, J., & Clement, F. (2020). Addendum to “hCG found in tetanus vaccine”: Examination of alleged “ethical concerns” based on false claims by certain of our critics. International Jouurnal of Vaccine Theory, Practice, and Research, 1(1), 27–50. https://doi.org/10.4236/oalib.1103937

Peirce, C. S. (1897). The logic of relatives. The Monist, 7(2), 161–217. http://archive.org/details/jstor-27897407

Pellegrino, P., Perrone, V., Pozzi, M., Carnovale, C., Perrotta, C., Clementi, E., & Radice, S. (2015). The epidemiological profile of ASIA syndrome after HPV vaccination: An evaluation based on the Vaccine Adverse Event Reporting Systems. Immunologic Research, 61(1), 90–96. https://doi.org/10.1007/s12026-014-8567-3

Pellionisz, A. J. (2012). The decade of fractogene: From discovery to utility—Proofs of concept open genome-based clinical applications. International Journal of Systemics, Cybernetics and Informatics, 17–28. http://www.junkdna.com/pellionisz_ieee_hyderabad/

Shaw, C. (2021). Dispatches From the Vaccine Wars. Skyhorse Publishing.

Shaw, C. A. (2017). Neural Dynamics of Neurological Disease. John Wiley & Sons, Inc. https://doi.org/10.1002/9781118634523.refs

Shaw, C. A. (2021). Dispatches from the Vaccine Wars. Skyhorse Publishing. https://www.simonandschuster.com/books/Dispatches-from-the-Vaccine-Wars/Christopher-A-Shaw/Children-s-Health-Defense/9781510758506

Shaw, C. A., Li, D., & Tomljenovic, L. (2014). Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy? Immunotherapy, 6(10), 1055–1071. https://doi.org/10.2217/imt.14.81

Shaw, C. A., Seneff, S., Kette, S. D., Tomljenovic, L., Oller, J. W., & Davidson, R. M. (2014). Aluminum-induced entropy in biological systems: Implications for neurological disease. Journal of Toxicology, 2014, 491316. https://doi.org/10.1155/2014/491316

Sheikh, S., Biundo, E., Courcier, S., Damm, O., Launay, O., Maes, E., Marcos, C., Matthews, S., Meijer, C., Poscia, A., Postma, M., Saka, O., Szucs, T., & Begg, N. (2018). A report on the status of vaccination in Europe. Vaccine, 36(33), 4979–4992. https://doi.org/10.1016/j.vaccine.2018.06.044

Shibata, A., & Kataoka, Y. (2019). Letters to the editor; a possible spurious correlation between human papillomavirus vaccination introduction and birth rate change in the United States. Hum Vaccin Immunother, 15(10), 2501–2502. https://doi.org/10.1080/21645515.2019.1586032

Shimabukuro, T. T., Kim, S. Y., Myers, T. R., Moro, P. L., Oduyebo, T., Panagiotakopoulos, L., Marquez, P. L., Olson, C. K., Liu, R., Chang, K. T., Ellington, S. R., Burkel, V. K., Smoots, A. N., Green, C. J., Licata, C., Zhang, B. C., Alimchandani, M., Mba-Jonas, A., Martin, S. W., … CDC v-safe COVID-19 Pregnancy Registry Team. (2021). Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. The New England Journal of Medicine, 384(24), 2273–2282. https://doi.org/10.1056/NEJMoa2104983

Siel, D., Loaiza, A., Vidal, S., Caruffo, M., Paredes, R., Ramirez, G., Lapierre, L., Briceno, C., Perez, O., & Saenz, L. (2018). The immune profile induced is crucial to determine the effects of immunocastration over gonadal function, fertility, and GnRH-I expression. American Journal of Reproductive Immunology, 79(1). https://doi.org/10.1111/aji.12772

Siel, D., Ubilla, M. J., Vidal, S., Loaiza, A., Quiroga, J., Cifuentes, F., Hardman, T., Lapierre, L., Paredes, R., & Saenz, L. (2020). Reproductive and Behavioral Evaluation of a New Immunocastration Dog Vaccine. Animals, 10(2), 226. https://doi.org/10.3390/ani10020226

Sundaram, A., Vaughan, B., Kost, K., Bankole, A., Finer, L., Singh, S., & Trussell, J. (2017). Contraceptive Failure in the United States: Estimates from the 2006-2010 National Survey of Family Growth. Perspect Sex Reprod Health, 49(1), 7–16. https://doi.org/10.1363/psrh.12017

Talwar, G. P., Sharma, N. C., Dubey, S. K., Salahuddin, M., Das, C., Ramakrishnan, S., Kumar, S., & Hingorani, V. (1976). Isoimmunization against human chorionic gonadotropin with conjugates of processed beta-subunit of the hormone and tetanus toxoid. Proceedings of the National Academy of Sciences, 73(1), 218–222. https://doi.org/10.1073/pnas.73.1.218

Tarski, A. (1949). The semantic conception of truth. In H. Feigl & W. Sellars (Eds.), Readings in Philosophical Analysis (pp. 341-374.). Appleton.

Tarski, A. (1956). The concept of truth in formalized languages. In J. J. Woodger (Ed.), Logic, Semantics, and Metamathematics (pp. 152–278). Oxford University Press.

Taylor & Francis Online. (2019, December). Statement of Retraction: RETRACTED ARTICLE: [A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection]. https://www.tandfonline.com/doi/abs/10.1080/15287394.2018.1477640

U.S. Food & Drug Administration. (2006). Approved Products—June 8, 2006 Approval Letter—Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant [WebContent]. Center for Biologics Evaluation and Research. http://wayback.archive-it.org/7993/20170722145339/ https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm111283.htm

U.S. Food & Drug Administration. (2020, June 15). Gardasil 9. FDA; FDA. https://www.fda.gov/vaccines-blood-biologics/vaccines/gardasil-9

Yan, G., Schoenfeld, D., Penney, C., Hurxthal, K., Taylor, A. E., & Faustman, D. (2000). Identification of premature ovarian failure patients with underlying autoimmunity. Journal of Women’s Health & Gender-Based Medicine, 9(3), 275–287. https://doi.org/10.1089/152460900318461

Yang, Y., Jia, C.-W., Ma, Y.-M., Zhou, L.-Y., & Wang, S.-Y. (2013). Correlation between HPV sperm infection and male infertility. Asian Journal of Andrology, 15(4), 529–532. https://doi.org/10.1038/aja.2013.36

cover image of volume 2 issue 1




How to Cite

DeLong, G. (2021). Lowered Female Fertility Associated with Human Papilloma Virus Vaccines. International Journal of Vaccine Theory, Practice, and Research, 2(1), 125–148. https://doi.org/10.56098/ijvtpr.v2i1.31